Updated Questions and Answers related to the dengue vaccine Dengvaxia® and its use

This document takes into account new and unpublished data that were communicated by Sanofi Pasteur to WHO in November-December 2017.

WHO published the recommendations of the Strategic Advisory Group of Experts on Immunization (SAGE) on the use of Dengvaxia® on 27 May 2016 (1), and subsequently a WHO position paper on dengue vaccine on 29 July 2016 (2).

Following the disclosure to WHO of new data on Dengvaxia® by its manufacturer, Sanofi Pasteur, as described in more detail below, WHO has initiated a process engaging independent external experts to review the data in detail. This process is expected to lead to revised recommendations from SAGE in April 2018, and to an updated WHO position paper on dengue vaccine thereafter.

The purpose of this document, prepared by the WHO Secretariat, is to supplement the WHO position paper on Dengvaxia® of July 2016 until WHO has issued an updated position paper on dengue vaccine, based on advice by SAGE. WHO Secretariat recommends that the July 2016 position paper be read in conjunction with this document.

This document replaces a questions and answers document web-posted by WHO on 30 November 2017.